Microneedling

Reveal Rejuvenated Skin with Advanced Microneedling + Regenerative Therapies. Stimulate your skin’s natural healing for smoother, firmer, more luminous skin.

Why Microneedling?

Microneedling (also called collagen induction therapy) uses ultra-fine sterile needles to create microscopic channels in the skin. These micro-injuries trigger your body’s natural wound-healing cascade—boosting collagen and elastin production to renew and rejuvenate your skin.

When combined with adjuvants like EXO exosomes, red light, or Ultra+, the regenerative response is enhanced: deeper repair, better tone, and more lasting radiance.

At Rejuvenate Indy, our microneedling is not one-size-fits-all. We build a layered, high-performance protocol designed to maximize repair, minimize downtime, and deliver visible results. Our approach is:

Collagen PIN — The Foundation of Precision Microneedling

We use Collagen PIN, an FDA-registered automated microneedling device featuring a 36-pin needle array and adjustable depth up to 3 mm. Collagen P.I.N.
Advantages include:

  • Consistent, controlled penetration across areas

  • Faster sessions and enhanced comfort

  • Reduced dragging or tearing compared to older tools

  • Reliable reproducibility of results

Because it’s motorized and calibrated, Collagen PIN gives us clinical-level predictability for every treatment.

EXO / EXO|E — Plant-Derived Exosomes for Regeneration

At Rejuvenate Indy, we utilize EXO|E — a next-generation, plant-based system of secretory factors and micro-vesicles.

  • These are plant-derived, not human or animal-based, which can reduce immunologic risk while still being biologically active.

  • They carry signaling molecules (peptides, growth factors, liposomes) that help modulate inflammation, stimulate collagen/fibroblast pathways, and support repair.

  • Because microneedling creates micro-channels, EXO|E acts like a “booster infusion” — penetrating deeper via those channels to enhance outcomes

In short: EXO|E turns a microneedling session into a full regenerative cocktail.

PDRN: Advanced DNA-Based Regeneration

PDRN (Polydeoxyribonucleotide) is a highly purified fragment of DNA — often derived from salmon (or similar sources) — that’s used in regenerative aesthetic medicine for its powerful healing and renewing effects.

How It Works (At the Cellular Level)

  • Activates repair pathways: PDRN engages adenosine A2A receptors, which helps initiate biochemical cascades tied to wound healing, collagen synthesis, and fibroblast activation.

  • Stimulates collagen & elastin production: It encourages the formation of new dermal matrix, improving firmness, elasticity, and skin structure.

  • Reduces inflammation & aids microcirculation: Helps calm redness and swelling, and supports better blood flow to damaged areas — accelerating tissue repair.

  • Supports DNA repair & cellular regeneration: The nucleotides in PDRN can provide building blocks for cellular repair, helping skin recover after trauma or injury.

Why We Offer PDRN in Your Treatment Protocol
When combined with microneedling (which creates microchannels), PDRN’s penetration is enhanced — allowing it to reach deeper skin layers and deliver regenerative power precisely where it’s needed. We may layer PDRN either in conjunction with EXO|E or as an optional enhancement in our protocols, depending on individual skin goals.

PDRN is especially useful when clients want:

  • Extra repair support (e.g. post-treatment or for sensitive skin)

  • Enhanced collagen remodeling

  • Quicker recovery (less redness, faster healing)

  • Support for textural concerns or mild scarring

Ultra+ Enhancement (Selective Boost Mode)

In zones requiring extra push — like deep lines, textured areas, or stubborn scars — we layer Ultra+. Think of it as the “turbo” mode in our toolkit: it helps drive actives deeper, heighten collagen stimulation, or support more aggressive remodeling.

Ultra+ works synergistically with Collagen PIN + EXO to lift performance beyond just one modality.

Celluma Red Light Therapy — Calming, Healing, Supporting

We cap your session with Celluma® red / near-infrared LED therapy (medical-grade). This helps:

  • Reduce post-treatment redness and inflammation

  • Accelerate healing via mitochondrial stimulation

  • Support collagen remodeling

  • Provide comfort and recovery support

Because it’s medical-grade (rather than consumer LED mask equipment), we can deliver consistent therapeutic levels of light for better penetration and predictable outcomes.

Benefits of Microneedling

Benefits

Boosts Collagen Production: Stimulates natural collagen and elastin for firmer, more youthful skin.

  1. Enhances Skin Texture: Reduces the appearance of fine lines, wrinkles, and uneven skin tone.

  2. Accelerates Healing: Exosomes speed up the skin's natural repair process for faster results.

  3. Minimizes Pores: Helps shrink the appearance of large pores for a smoother complexion.

  4. Reduces Scarring: Improves the appearance of acne scars, surgical scars, and other blemishes.

  5. Brightens Skin: Promotes a radiant and glowing complexion by enhancing cell turnover.

  6. Improves Hydration: Supports the skin barrier, locking in moisture and enhancing hydration.

  7. Targets Pigmentation: Reduces hyperpigmentation and dark spots for a more even skin tone.

  8. Long-Lasting Results: Combines the immediate benefits of microneedling with the regenerative effects of exosomes for enduring improvements.

  9. Non-Surgical Rejuvenation: Offers a minimally invasive alternative to more invasive procedures.

Pricing

What to Expect: Before, During & After

Before Your Appointment: D|TOX + Hydration Preparation

We begin your microneedling journey with a skin D|TOX prep to optimize results — and it also primes your skin for hydration.

D|TOX & hydration benefits:

  • Removes surface buildup (dead skin cells, oil, impurities) to unclog pores

  • Lowers baseline inflammation or congestion

  • Allows deeper, more even penetration of treatment actives

  • Boosts hydration by clearing barriers (debris, excess sebum) so moisture and actives are better absorbed

Prep guidelines (3–5 days before):

  • Use gentle cleansers, hydrating masks, and lightweight, non-occlusive moisturizers

  • Avoid heavy creams, pore-clogging products, or makeup

  • Discontinue strong actives (retinols, acids) for several days

  • Drink plenty of water and support your body’s natural detox (nutrient-rich diet, sleep)

During Treatment: Precision + Regeneration

Your treatment follows our advanced, layered protocol:

  1. Microneedling with Collagen PIN for consistent microchannel creation

  2. EXO / EXO|E infusion (plant-derived exosomes) to enhance cellular signaling and repair

  3. Ultra+ enhancement in targeted zones (if applicable)

  4. Celluma red light therapy (medical-grade) to calm, support recovery, and boost mitochondrial repair

After Treatment: Repair, Recovery & Inclusion of EXO|GLO Mask

After your session, we move into the repair phase — and every microneedling package includes the next step:

EXO|GLO 24K Gold Collagen Mask (included in all packages)
This mask is a luxury post-care treatment designed to soothe, hydrate, and enhance your results. The EXO|GLO mask features:

  • Pure 24K gold leaf to help reduce visible inflammation, fine lines, and enhance radiance

  • Collagen + hydrating agents to support barrier repair, moisture retention, and suppleness

  • Ultra-hydrating, restorative formula that brightens and replenishes skin post-treatment

Why this mask matters:

  • Helps calm redness and soothe the skin immediately after microneedling

  • Reinforces barrier recovery and locks in hydration

  • Enhances glow and complements the regenerative actives applied during treatment

RE|PAIR: Your Post-Treatment Repair Serum

What is RE|PAIR?
RE|PAIR is a take-home, plant-based biomimetic serum that reinforces the regenerative signals delivered during treatment. It’s part of the EXO|E system and is designed to fortify healing, soothe, and support recovery.

Key Benefits of RE|PAIR

  • Reinforces the messaging of EXO|E to amplify repair and healing post-procedure

  • Supports the transition into the proliferative phase (when new skin tissue is rebuilt)

  • Helps soothe and calm sensitive or post-procedure skin

  • Promotes barrier repair and keeps the skin hydrated and resilient

  • Made of plant secretory factors, liposomes, and extracellular nanoparticle technology (ENPT) for advanced compatibility and performance

  • Works in synergy with EXO|E and other regenerative treatments, helping optimize outcomes and reduce downtime

Aftercare tips:

  • Use cool compresses or soothing serums as needed

  • Avoid makeup, sweating, and saunas for ~24 hours

  • Apply gentle, restoring moisturizers and avoid active ingredients initially

  • Shield skin with broad-spectrum SPF moving forward

  • Expect mild redness or warmth for 24–72h; glow should appear early, with deeper improvements over time

Frequently Asked Questions

  • Microneedling with exosomes combines the collagen-stimulating benefits of microneedling with the regenerative power of exosomes. These tiny, stem-cell-derived vesicles enhance skin healing and rejuvenation, promoting faster and more visible results.

  • This treatment targets fine lines, wrinkles, acne scars, uneven skin tone, enlarged pores, pigmentation, and dullness, helping to rejuvenate and refresh your complexion.

  • Yes, microneedling with exosomes is a minimally invasive and safe procedure when performed by a trained professional. It’s suitable for most skin types and offers minimal downtime.

  • The treatment begins with applying a small amount of exosomes, followed by numbing cream for your comfort. Microneedling is then performed, and the exosomes are reapplied to enhance absorption and results.

  • Most patients see optimal results after 3-4 sessions spaced 4-6 weeks apart. Your provider will create a personalized treatment plan based on your goals.

  • Downtime is minimal, typically lasting about 2 days. You may experience redness, mild swelling, or sensitivity during this time.

  • Initial improvements can be seen within a week, with continued enhancements over the next few months as collagen production increases and the exosomes take effect.

  • Common side effects include redness, mild swelling, and a sensation similar to a mild sunburn. These typically subside within a day or two.

    • EXO / Exosomes are microscopic “messenger” vesicles that send signals to your skin cells—encouraging repair, collagen production, and regeneration.

    • PDRN (Polydeoxyribonucleotide) is a purified DNA fragment that helps stimulate tissue repair, reduce inflammation, and support structural healing.

  • With numbing, most people feel mild pressure or tingling only. Discomfort is minimal.

Ready to reveal your most radiant skin? Book your facial microneedling session today and experience the power of rejuvenation! Glow confidently with smoother, healthier skin. Limited spots available—reserve yours now!

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